CAC_MISC 5-1993, Amended 2003 Glossary Of Terms And Definitions (Residues Of Veterinary Drugs In Foods)
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1FB367160285484F834E52E7B54886DB |
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0.04 |
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页数： |
4 |
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日期： |
2004-12-27 |
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文本摘录（文本识别可能有误，但文件阅览显示及打印正常，pdf文件可进行文字搜索定位）：
CAC/MISC 5-1993 Page 1 of 4,GLOSSARY OF TERMS AND DEFINITIONS,(Residues of Veterinary Drugs in Foods),(CAC/MISC 5-1993, Amended 2003),FOREWORD,The Glossary of Terms and Definitions has been elaborated by the Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF) with a view towards providing information and guidance to the Committee, and is intended for internal Codex use only.,The Glossary is intended to be an open list which is subject to review by the CCRVDF in order to update, modify or add to the list of terms. Relevant terms elaborated by other Codex Committees are included. Attention is drawn to the Notes following.,1. Acceptable Daily Intake (ADI): An estimate by JECFA of the amount of a veterinary drug, expressed on a body weight basis, that can be ingested daily over a lifetime without appreciable health risk (standard man = 60 kg) (See Note 3).,2. Bioavailable Residues: Those residues that can be shown, by means of an appropriate method (e.g. Gallo-Torres method) to be absorbed into systemic circulation when fed to laboratory animals (See Note 3).,3. Bound Residue: Residues derived from the covalent binding of the parent drug or a metabolite of the drug and a cellular biological soluble or insoluble macromolecule. These residues are not extractable from the macromolecule by exhaustive extraction, denaturation or solubilization techniques. They do not result from the incorporation of metabolized, radiolabelled fragments of the drug into endogenous compounds, or the same macromolecule by normal biosynthetic pathways. Information concerning the calculation of bound residues may be found in Annex 3 of the 34th Report of JECFA (pages 58-61, WHO TRS 788).,4. Egg1 The fresh edible portion of the spheroid body produced by female birds, especially domestic fowl.,Portion of the commodity to which the MRL applies: The edible portion of the egg including the yolk and egg white after removal of the shell,5. Extractable Residue: Those residues extracted from tissues or biological fluids by means of aqueous acidic or basic media, organic solvents and/or hydrolysis with enzymes (e.g. sulfatase or glucuronidase) to hydrolyze conjugates. The extraction conditions must be such that the compounds of interest are not destroyed (See Note 2).,6. Fat 1: The lipid-based tissue that is trimmable from an animal carcass or cuts from an animal carcass. It may include subcutaneous, omental or perirenal fat. It does not include interstitial or intramuscular carcass fat or milk fat.,Portion of the commodity to which the MRL applies: The whole commodity. For fat-soluble compounds the fat is analysed and MRLs apply to the fat. For those compounds where the trimmable fat is insufficient to provide a suitable test sample, the whole commodity (muscle and fat but without bone) is analysed and the MRL applies to the whole commodity (e.g., rabbit meat).,1 Amendment adopted by the 26th Session of the Codex Alimentarius Commission.,CAC/MISC 5-1993 Page 2 of 4,7. Fish: Means any of the cold-blooded aquatic vertebrate animals commonly known as such. This includes Pisces, Elasmobranchs and Cyclostomes. Aquatic mammals, invertebrate animals and amphibians are not included. It should be noted, however, that this term may also apply to certain invertebrates, particularly Cephalopods.,8. Good Practice in the Use of Veterinary Drugs (GPVD): Is the official recommended or authorized usage including withdrawal periods, approved by national authorities, of veterinary drugs under practical conditions (See Note 1).,9. Marker Residue: A residue whose concentration decreases in a known relationship to the level of total residues in tissues, eggs, milk or other animal tissues. A specific quantitative analytical method for measuring the concentration of the residue with the required sensitivity must be available (See Note 3).,10. Maximum Residue Limit for Veterinary Drugs (MRLVD): Is the maximum concentration of residue resulting from the use of a veterinary drug (expressed in mg/kg or ìg/kg on a fresh weight basis) that is recommended by the Codex Alimentarius Commission to be legally permitted or recognized as acceptable in or on a food (See Note 1).,It is based on the type and amount of residue considered to be without any toxicological hazard for human health as expressed by the Acceptable Daily Intake (ADI), or on the basis of a temporary ADI that utilizes an additional safety factor. It also takes into account other relevant public health risks as well as food technological aspects.,When establishing an MRL, consideration is also given to residues that occur in food of plant origin and/or the environment……
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